恶化骨微型架构,由色细胞瘤和偏角细胞瘤的同情性过度刺激引起
1Department of Endocrinology, Key Laboratory of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Dongcheng District, National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan No.1, Wangfujing Street, Beijing, 100730, China.
Journal of endocrinological investigation
|October 23, 2023
概括
发红细胞瘤和偏角质瘤 (PPGL) 患者的交感过度刺激显著恶化了骨的微观结构和强度,特别是椎骨. 这表明同情活动可能是骨质疏松症的次要原因.
科学领域:
- 内分泌学和骨代谢 骨质代谢
- 心血管 - 骨相互作用
背景情况:
- 交感神经系统活动影响骨代谢,但其对骨微观结构和强度的具体影响仍未得到充分研究.
- 乳红细胞瘤和偏角细胞瘤 (PPGL) 是与过度交感活动相关的瘤,这使得它们成为研究这些影响的相关模型.
研究的目的:
- 评估交感活动对PPGL患者骨微架构和骨强度的影响.
- 调查PPGL患者的交感标记物和骨质参数之间的关系.
主要方法:
- 对38名PPGL患者和76名健康对照者的横截面研究.
- 测量骨循环标记物 (P1NP,β-CTX) 和24小时尿中类甲醇胺 (上腺素,北上腺素) 以评估同情活性.
- 高分辨率的外围定量计算断层扫描 (HR-pQCT) 用于DXA的骨微架构和面积骨矿物质密度 (aBMD).
主要成果:
- 与对照组相比,PPGL患者表现出较高的骨吸收标志物 (β-CTX) 和显著恶化的脊椎骨微架构 (Tb.N,Tb.Th降低;Tb.Sp增加) 和骨强度.
- 在PPGL患者中,在半径和骨中观察到体积 BMD (vBMD) 和骨强度的降低.
- 较高的24小时尿中诺亚上腺素水平与较差的小腿骨微观结构 (较低的TbN,较高的TbSp) 相相关.
结论:
- PPGL患者表现出明显受损的骨微架构和强度,表明骨再吸收增加.
- 正如PPGL中所见的交感过度刺激,可能是骨质疏松症的次要原因,特别是在交感活动增加的个体中.
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