与结肠镜检查相比,通过不同的阴囊程序进行结肠肌瘤的结肠分布 - - 使用对比液的概念验证研究
Linn Kallbekken Skjevling1,2, Hege Marie Hanssen1,2, Per Christian Valle2,3
1Medical Department, Research Unit, University Hospital of North-Norway Harstad, St. Olavs gt. 70, Harstad, Norway.
BMC gastroenterology
|October 23, 2023
概括
便微生物种移植 (FMT) 通过结肠镜检查到达整个结肠,而阴囊输送显示了有限的近端分布. 定位手术可能会略有改善阴囊的输送,但结肠镜对于到达阴囊仍然优越.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 医疗成像医学成像
背景情况:
- 便微生物种移植 (FMT) 是复发性Clostridioides difficile感染的关键治疗方法.
- 它的有效性与改变肠道微生物群有关,但输送方法及其对结肠分布的影响尚不清楚.
- 通过阴囊的FMT的近端分布在很大程度上是未知的.
研究的目的:
- 为了比较便微生物群移植 (FMT) 的近位分布,当通过结肠镜检查与阴囊进行输送时.
- 为了评估液后定位手术对FMT分布的影响.
主要方法:
- 一项涉及八名参与者的交叉研究中,给予了具有类似FMT粘度的对比液 (CF).
- 结肠炎是通过结肠镜检查和随后通过阴囊进行的,X射线用于可视化分布.
- 卷水输送被评估与或没有定位程序.
主要成果:
- 结肠镜检查确保了100%的对比液 (CF) 输送到盲肠和横肠.
- 50%的参与者使用定位手术,38%的参与者没有使用定位手术时,阴囊输送达到眼.
- 横横结肠CF分布在定位过程中为88%,没有定位过程时为63%.
结论:
- 结肠镜检查是最有效的方法,以确保FMT到达阴.
- 即使使用定位程序,阴囊输送也限制了近端结肠分布.
- 需要进一步的研究来将FMT分布与治疗结果相关联.
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