对于中等风险组非肌肉侵入性膀癌的最佳静脉内维持化疗方案
Jian-Xin Chen1,2,3, Wen-Ting Huang4, Qing-Yun Zhang2
1Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
BMC cancer
|October 23, 2023
概括
对于中等风险的非肌肉侵入性膀癌 (NMIBC),维持6个月以上的静脉内化学疗法显著改善了无复发的生存率. 这种治疗的最佳持续时间约为10.5个月,为精确的膀癌管理提供了宝贵的见解.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 目前欧洲泌尿病学协会 (EAU) 的指导方针建议在中等风险的非肌肉侵入性膀癌 (NMIBC) 中,在经过尿道切除膀瘤 (TURBT) 后,最多一年内进行静脉内化学疗法或Bacillus Calmette-Guerin (BCG).
- 在NMIBC中维持静脉内化疗的最佳持续时间仍未确定,缺乏共识.
研究的目的:
- 为了确定中等风险NMIBC患者维持静脉内化学疗法的最佳持续时间.
- 评估不同化疗灌注时间对瘤复发率的影响.
主要方法:
- 一个现实世界,单中心的回顾性队列研究,涉及158名中等风险NMIBC患者.
- 患者根据静脉内化疗插入次数分为四组.
- 考克斯回归分析,生存分析和接收器运行特征 (ROC) 曲线被用于评估3年复发结果.
主要成果:
- 平均随访时间为5.2年.
- 超过6个月的静脉内灌注化疗显示,与1-2个月相比,3年无复发存活率 (HR0.22,P=0.02) 显著改善.
- 通过ROC分析确定维护化疗的最佳持续时间是10.5个月.
结论:
- 在中等风险的NMIBC中,用pirrubicin进行静脉内灌注化疗的最佳持续时间是10.5个月.
- 这一发现有助于为中等风险的NMIBC提供更精确的医疗治疗模式.
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