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母亲血中的轻稀土元素与自发早产风险之间的关联:北京出生队列研究中的嵌套病例对照研究

Junxi Chen^1,2, Aili Wang^3,4, Hang An^1,2

¹Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, 100191, PR China.

Environmental health : a global access science source

|October 23, 2023

概括

在妊娠的第三季度接触稀土元素 (REEs) 与自发早产 (SPB) 亚型的风险增加有关. 兰和可能会增加自发早产 (SPL) 的风险,而可能会增加早产前膜破裂 (PPROM) 的风险.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
围产期流行病学围产期流行病学

背景情况:

父母接触稀土元素 (REEs) 是自发早产 (SPB) 的潜在危险因素.
SPB的亚型,包括自发早产 (SPL) 和早产前膜破裂 (PPROM),可能表现出对环境暴露的不同敏感性.
调查三个月特定的REE暴露对于了解SPB病因至关重要.

研究的目的:

检查不同怀孕季度的稀土元素 (REE) 暴露与自发早产 (SPB) 风险之间的关联.
调查REE暴露和SPB亚型之间的潜在差异性关联:自发早产 (SPL) 和早产前膜破裂 (PPROM).

主要方法:

一项嵌套的病例控制研究包括244例SPB病例和244例具有满期分娩的对照.
在第一和第三季度量化了光REEs的等离子体度.
后勤回归和贝叶斯内核机器回归 (BKMR) 用于分析与SPB及其子类型的REE暴露关联.

主要成果:

第三季度暴露于光REE与SPB及其亚型有关.
增加的SPL风险与中等和最高三分之一的兰 (La) 和最高三分之一的萨马 (Sm) 暴露有关.
(Pr) 暴露的最高三位数与PPROM的风险增加有关.

结论:

(La) 和 (Sm) 的血含量可能与自发早产 (SPL) 的风险增加有关.
(Pr) 的血含量可能与早产早破膜 (PPROM) 的风险增加有关.
孕期特异性的REE暴露,特别是在孕期第三季度,需要进一步调查与早产有关的问题.

关键词:

嵌套病例控制研究研究.膜的过早破裂过早的过早破裂稀土元素稀土元素是一种稀土元素.自发的早产,即早产.自发的早产劳动

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