系统性硬化和支气管切除风险:全国纵向队列研究
Bumhee Yang1, Bo-Guen Kim2, Kyungdo Han3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Arthritis research & therapy
|October 23, 2023
概括
患有全身性硬化症的个体患上支气管切除症的风险明显更高. 这表明支气管切除可能是系统性硬化症的肺部表现.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 系统性硬化症和支气管切除症之间的关系尚未得到充分证实.
- 系统性硬化症是一种影响连接组织的自身免疫性疾病.
研究的目的:
- 为了研究系统性硬化症和支气管切除症的发生率之间的关联.
- 为了比较系统性硬化症患者与对照者的支气管切除风险.
主要方法:
- 利用韩国国家医疗保险服务的全国纵向数据集 (2010-2017年).
- 包括4845名全身性硬化症患者和24225名匹配对照 (1:5).
- 追踪参与者直到诊断,死亡或2019年底.
主要成果:
- 5.3%的全身性硬化症患者患有支气管切除症,对照组为1.9%.
- 系统性硬化症中支气管切除症的调整后危险比为2.63 (95% CI 2.22-3.12).
- 在较年轻的全身性硬化症患者 (20-39岁) 和没有其他结缔组织疾病的患者中观察到更高的风险.
结论:
- 系统性硬化症显著增加了发展支气管切除症的风险.
- 支气管切除应被认为是系统性硬化症的潜在肺部并发症.
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