遗传学对影响永久牙和初级牙的牙下矿化发生的影响:一个范围审查
Thamires Pereira de Souza Teixeira1, Patricia Soares Araújo Pereira1, Felipe de Assis Ribeiro Carvalho1
1Department of Preventive and Community Dentistry, Faculty of Dentistry, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
International journal of paediatric dentistry
|October 24, 2023
概括
遗传因素可能有助于切口低矿化 (MIH),这是儿童常见的牙科问题. 然而,目前的研究是有限的,需要进一步的遗传研究,以充分理解MIH.
科学领域:
- 牙科研究 牙科研究
- 遗传学 遗传学是一种遗传学.
- 儿科牙科 儿科牙科
背景情况:
- 牙切口低矿化 (MIH) 是一种广泛的牙疾病,影响着全球儿童.
- 人们认为MIH是一种多因素的疾病,受到环境和遗传因素的影响.
研究的目的:
- 进行范围审查,以确定对MIH病因学遗传影响的现有证据.
- 综合研究中的研究结果,研究在发展的遗传因素 摩尔切口的低矿化.
主要方法:
- 在主要数据库 (PubMed,BVS,Embase,Web of Science,Scopus) 中采用了全面的搜索策略.
- 审查遵循了乔安娜·布里格斯研究所的协议,由两名训练有素的审查员收集证据.
- 从最初检索的563篇文章中,包括了17项研究.
主要成果:
- 该审查包括14项人类研究和3项动物研究.
- 人类研究的重点是DNA多态性 (10),DNA甲基化 (1),遗传模型 (1) 和家族/双胞胎表型 (2).
- 动物研究检查了特定基因的零表达.
结论:
- 这些发现支持了对MIH多因素病因学的遗传贡献假设.
- 目前的证据受样本大小和原产地限制.
- 进一步的遗传研究对于阐明基因在MIH中的作用至关重要.
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