凯文-2促进纤维细胞转移到肌纤维细胞的转移差异化,并加剧心脏纤维化

Yusuke Higuchi1, Takehiro Ogata1,2, Naohiko Nakanishi1

  • 1Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

ESC heart failure
|October 24, 2023
PubMed
概括

卡-2 缺乏通过抑制纤维细胞激活和转化增长因子-β (TGF-β) 信号传递,显著减少心脏纤维化. 这一发现表明Cavin-2是治疗心脏纤维化的潜在治疗标.

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