大脑干前运动机制是声乐生产和声呼吸协调的基础
bioRxiv : the preprint server for biology
|October 24, 2023
概括
研究人员确定了控制声带关闭和小鼠发声的特定神经元. 这些神经元协调呼吸和声音模式,揭示了语音生产的关键神经回路.
科学领域:
- 神经科学是一个神经科学.
- 发音神经科学 发音神经科学
- 呼吸系统神经科学 呼吸系统神经科学
背景情况:
- 精确控制喉肌肉和与呼吸的协调对于语音生成至关重要.
- 声呼吸合的基础的神经机制在很大程度上是未知的.
研究的目的:
- 在成年小鼠中绘制喉前运动回路的图.
- 确定负责声格式生成和声呼吸合的特定神经群体.
主要方法:
- 病毒遗传追踪用于识别和操纵特定的神经元群体.
- 电生理学记录以评估神经元活动.
- 行为测试用于测量超声波发声 (USV) 和呼吸模式.
主要成果:
- 在反复模糊核 (RAmVOC) 中的激发性声声前运动神经元被确定为声带关闭和引起USVs的必要和充分.
- RAmVOC神经元激活的持续时间直接影响USV音节长度和灵感后阶段.
- RAmVOC神经元从preBötzinger复合体接收抑制输入,使呼吸需要进入声带关闭.
- 在RAmVOC神经元中抑制突触的破坏导致发声和呼吸的脱.
结论:
- 发现了控制语音模式生成和语音-呼吸器合的神经回路.
- 证明RAmVOC神经元是发声模式生成和声呼吸合的关键节点.
- 在RAmVOC神经元中抑制突触的切除破坏了灵感门,将发声与呼吸脱.
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