母亲暴露于空气污染和婴儿肺功能之间的关联是由对氧化应激的遗传倾向改变的
medRxiv : the preprint server for health sciences
|October 24, 2023
概括
产前暴露于二氧化 (NO2) 与患有氧化应激 (OS) 的遗传倾向的婴儿的婴儿肺功能降低有关. 这项研究强调了遗传风险因素如何改变空气污染.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 空气污染和呼吸道问题之间确立的联系,特别是在儿童中.
- 对生物机制的理解有限,特别是在产前暴露方面.
- 儿童发育中的器官在怀孕期间极易受到环境因素的影响.
研究的目的:
- 为了研究孕妇在怀孕期间暴露于空气污染和婴儿在4周的肺功能之间的联系.
- 检查妊娠期间氧化应激 (OS) 和炎症标志物的作用.
- 为了确定婴儿对OS的遗传倾向是否会改变空气污染对肺功能的影响.
主要方法:
- 长度巴沃恩婴儿研究 (BIS) 队列.
- 使用卫星模型估计的母亲对NO2和PM2.5的暴露.
- 通过多次呼吸洗测量婴儿肺功能;在母体和带血液中分析了OS和炎症生物标志物;计算了OS的遗传风险得分.
主要成果:
- 没有发现母亲暴露于空气污染和婴儿肺功能之间的总体关联.
- 暴露于二氧化 (NO2) 与具有高遗传OS风险的婴儿的功能残留能力 (FRC) 较低有关.
- 在基因易患OS的婴儿中,较高的NO2暴露与增加的肺清除指数 (LCI) 相相关.
结论:
- 高产前NO2暴露与婴儿肺功能受损 (较低的FRC,较高的LCI) 相关,特别是在对氧化应激有遗传倾向的婴儿中.
- 没有观察到母亲的空气污染与妊娠炎症或OS生物标志物之间的关联.
- 遗传易感性对产前空气污染如何影响生命早期呼吸系统健康起着至关重要的作用.
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