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Updated: Jul 12, 2025

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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Published on: June 23, 2022

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lysosomal 蛋白质学揭示了神经元 apoE4 相关的 lysosomal 功能障碍的机制

Einar K Krogsaeter1,2,3,4, Justin McKetney1,2,3,4, Leopoldo Valiente-Banuet5

  • 1Gladstone Data Science and Biotechnology Institute, The J. David Gladstone Institutes, San Francisco, California, USA.

bioRxiv : the preprint server for biology
|October 24, 2023
PubMed
概括

阿波利波蛋白E4 (ApoE4),阿尔茨海默氏症 (AD) 的风险因素,通过改变 lysosomal 蛋白质,损害 lysosomal 功能. 这项研究揭示了ApoE4导致神经元中的溶酶体化和蛋白质变化.

关键词:
阿尔茨海默病 阿尔茨海默病在Lgals3bpp.这就是LysoIP的意义.在Tmed5med5中使用.在 apoE4E4 中.lysosomes 溶解体 溶解体 是一种溶解体.它们的pH值为pH.

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