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Updated: Jul 12, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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蛋白质组分析揭示了一个PLK1-依赖的G2/M降解程序,并将PKA-AKAP2与细胞周期控制联系起来

Ryan D Mouery1,2, Carolyn Hsu2, Thomas Bonacci2,3

  • 1Curriculum in Genetics and Molecular Biology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

bioRxiv : the preprint server for biology
|October 24, 2023
PubMed
概括

这项研究揭示了Polo样酶1 (PLK1) 在细胞分裂过程中主导广泛的蛋白质降解. 这种调节会影响细胞循环,并对癌症产生影响,特别是当PLK1失调时.

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