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Updated: Jul 12, 2025

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质母细胞瘤的发起,迁移和细胞类型由核心bHLH转录因子ASCL1和OLIG2调节

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    bioRxiv : the preprint server for biology
    |October 24, 2023
    PubMed
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    致癌突变破坏了ASCL1和OLIG2的调节,这些突变冗余地启动了质母细胞瘤 (GBM) 的形成. 它们的动态相互作用决定了瘤细胞类型和迁移,高ASCL1定义了质瘤干细胞 (GSCs).

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