逆向可以积累平衡的性对抗性:来自模拟和果虫实验的证据
Christopher S McAllester1, John E Pool1
1Laboratory of Genetics, University of Wisconsin - Madison, USA.
bioRxiv : the preprint server for biology
|October 24, 2023
概括
染色体逆转由于对抗性形性而持续存在,其中等位基因会影响相反的特征,从而导致频率依赖的选择. 这个模型解释了逆向如何保持种群中的遗传多样性.
科学领域:
- 进化遗传学的进化遗传学
- 人口遗传学 人口遗传学
- 分子进化的分子进化.
背景情况:
- 染色体反转多态是常见的,但它们的持久性机制仍然不清楚.
- 了解维护遗传变异的进化力量是进化生物学中的一个核心问题.
研究的目的:
- 提出并测试一种用于维持反转多态的模型.
- 为了研究对抗性性和频率依赖性选择在反转动力学中的作用.
- 为了检查与Drosophila melanogaster*的逆转相关的性别特异性健身效应.
主要方法:
- 开发和应用一个先进的种群遗传学模拟器.
- 在生存和男性表现之间进行权衡,模拟对抗性类型.
- 实验室交叉 * Drosophila melanogaster * 追踪反转频率和健身组件.
主要成果:
- 模拟生成了与逆转相关的哈普洛类型,具有相反的性别特异性健康效应.
- 两个 *Drosophila melanogaster* 倒置, *ln(3R) K* 和 *ln(3L) Ok*, 显示了拟议的权衡的证据.
- *ln(3R) K*有利于女性的生存,而 *ln(3L) Ok*有利于男性的生殖成功,并具有性别特异性的生存成本.
结论:
- 在对抗性的类特征上平衡选择可以保持反转多态.
- 这种机制为自然逆向多样性提供了显著而被低估的贡献.
- 逆转可以通过减少重组负载来促进对抗变体的积累.
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