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Updated: Jul 12, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

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时钟激活剂赫西丁和一个新的衍生品的抗基性质

Xuekai Xiong, Tali Kiperman, Weini Li

    bioRxiv : the preprint server for biology
    |October 24, 2023
    PubMed
    概括

    新的小分子激活昼夜时钟,抑制脂肪细胞的发展. 这一发现通过准时钟功能,为肥胖和相关代谢障碍提供了潜在的治疗方法.

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    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads07:59

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    Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

    Adrenergic Agonists: Chemistry and Structure-Activity Relationship

    Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
    Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
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