循环衰老的髓状细胞驱动血脑屏障的破坏和神经退行
bioRxiv : the preprint server for biology
|October 24, 2023
概括
神经退行性疾病与具有BRAF V600E突变的髓状细胞有关. 准这些细胞中的MAPK和衰老可能会治疗Langerhans细胞细胞症患者的神经退行症.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 神经退行性疾病 (ND) 涉及渐进性神经元损失,病原体不明,阻碍有效治疗.
- 朗格汉斯细胞囊细胞症 (LCH) 是一种由MAPK突变的髓状细胞驱动的瘤疾病,一些患者患上不可治愈的神经退行症 (LCH-ND).
结论:
- 循环髓状细胞中的MAPK激活和衰老是LCH-ND的关键驱动因素.
- 阻断MAPK活动和衰老通路显示出治疗潜力,减少神经炎症并改善临床前模型中的神经结果.
- 这些途径代表了治疗与LCH相关的神经退行症的新型治疗点.
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