关于开发工具 (INSPECT-SR) 的协议,用于在卫生干预措施的系统审查中识别有问题的随机对照试验
Jack Wilkinson1, Calvin Heal1, George A Antoniou2,3
1Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
medRxiv : the preprint server for health sciences
|October 24, 2023
概括
一个名为INSPECT-SR的新工具将评估系统性审查中使用的随机对照试验 (RCT) 的可靠性. 这旨在防止虚假数据影响医疗保健决策和系统审查结论.
科学领域:
- 卫生研究方法论 卫生研究方法论
- 证据综合 证据综合
- 临床试验完整性的临床试验完整性
背景情况:
- 随机对照试验 (RCT) 对医疗保健决策至关重要,但有些含有伪造或虚假数据.
- 系统性审查综合了RCT,但通常不评估数据的可靠性,允许有缺陷的研究影响结论.
- 在已发表的RCT中存在不可靠的数据,这对医疗保健证据的完整性构成重大风险.
研究的目的:
- 开发INSPECT-SR工具,用于在医疗保健系统性审查中评估RCT的可信性.
- 通过识别和减轻有问题的RCT的影响,提高系统审查的可靠性.
主要方法:
- INSPECT-SR工具将通过五个阶段的过程开发,涉及专家共识和经验证据.
- 阶段包括专家调查,可行性评估,德尔菲调查,共识会议和系统审查中的前性测试.
主要成果:
- 该项目预计将开发一种新型工具,以识别具有潜在虚假或伪造数据的RCT.
- 该工具旨在提高系统审查中合成的证据质量.
结论:
- 预计INSPECT-SR工具将通过识别不值得信赖的RCT来提高系统审查的可靠性.
- 通过检测和排除含有虚假数据的研究,该工具将保护患者免受潜在有害的医疗保健建议.
- 该倡议旨在提高证据综合的质量,并保护基于证据的医疗保健实践.
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