侧侧内皮层子群代表围绕奖励的经验时代
John B Issa1, Brad A Radvansky1, Feng Xuan1
1Department of Neurobiology, Northwestern University, Evanston, IL 60608, USA.
bioRxiv : the preprint server for biology
|October 24, 2023
概括
鼠标的侧侧脑内皮层 (LEC) 编码了不同的神经群体,代表目标接近,离开和导航期间的奖励消耗. 这种以奖励为中心的信息对于灵活的导航和情节性记忆形成至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 行为科学 行为科学
背景情况:
- 目标导向导航依赖于整合.
- "什么" (经验) 和"在哪里" (空间) 的信息.
- 海马体也参与了这种整合,它从中枢内腔皮层 (MEC) 接收空间数据.
- 神经源和"什么"信息的表示在很大程度上仍然没有特征.
研究的目的:
- 为了研究侧腔内耳皮层 (LEC) 在基于奖励的导航过程中代表体验信息的作用.
- 在LEC中识别特定的神经元群体,编码导航任务的不同阶段.
- 为了确定LEC活动是否对学习至关重要,奖励位置变化.
主要方法:
- 在小鼠中开发一种新的成像技术.
- 在基于奖励的导航任务期间,记录LEC中的神经活动.
- 利用光遗传学来抑制LEC活动.
主要成果:
- 在LEC中识别出不同的神经元群体,信号目标接近,目标偏离和奖励消费.
- 证明这些LEC神经元群体在奖励位置发生变化时迅速调整其表征.
- 表明光遗传抑制LEC损害了学习新的奖励位置.
结论:
- LEC为围绕奖励消费的体验时代提供了一个稳定的神经代码.
- 来自LEC的这种以奖励为中心的信息补充了来自MEC的空间信息.
- 平行LEC和MEC表示支持情节记忆和灵活的目标导航.
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