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在C57BL/6J小鼠中的胰腺β细胞生理和葡萄糖恒温的性别差异
Seokwon Jo1, Megan Beetch1, Eric Gustafson1
1Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Journal of the Endocrine Society
|October 24, 2023
概括
雌性小鼠表现出比雄性更好的葡萄糖代谢和胰岛素耐受性,在C57BL/6J小鼠中,明显的胰腺β细胞对胰岛素耐药性的反应在6个月大时出现.
科学领域:
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
- 身体生理学 身体生理学
背景情况:
- 最近的任务强调性别作为研究中的生物变量.
- 在代谢研究中对正常生理性性别差异的理解有限.
研究的目的:
- 描述葡萄糖代谢中的性别依赖差异.
- 在正常条件下的雄性和雌性C57BL/6J小鼠中研究胰腺β细胞生理学.
主要方法:
- 使用C57BL/6J小鼠,这是代谢研究中常见的菌株.
- 评估葡萄糖和胰岛素耐受性,非禁食血糖和胰岛素水平.
- 分析了β细胞质量和营养感知通路中的分子变化.
主要成果:
- 与3个月和6个月的雄性相比,雌性小鼠表现出改善的葡萄糖和胰岛素耐受性,血糖和胰岛素水平较低.
- 贝塔细胞质量在两性都扩大,直到6个月没有差异.
- 与雌性不同的是,雄性小鼠在6个月后对胰岛素耐药性的反应中表现出增加的β细胞质量.
- 在O-GlcNAc转移酶和mTOR蛋白水平以及葡萄糖刺激合中观察到性二态.
结论:
- 在C57BL/6J小鼠中,葡萄糖代谢和胰岛素耐受性存在显著的性别差异.
- 胰腺β细胞质量和功能表现出性二态反应,特别是在胰岛素抵抗下.
- 调节营养感知和葡萄糖代谢的分子通路有助于观察到的性别差异.
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