骨肉瘤的描述性流行病学和生存率:中东地区第一个基于全国人口的研究 (2008-2014)
Amin Karimi1, Adel Ebrahimpour2, Mehrdad Sadighi2
1Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
The archives of bone and joint surgery
|October 24, 2023
概括
这项研究分析了伊朗骨髓瘤 (OS) 流行病学,发现每百万发病率为3.02. 一年后的生存率为87%,三年后为61%,五年后为49%.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 骨髓瘤 (OS) 是最常见的原发性骨肉瘤.
- 此前,中东地区,特别是伊朗的OS流行病学数据缺乏.
- 了解OS流行病学对于公共卫生倡议和治疗策略至关重要.
研究的目的:
- 调查伊朗骨髓瘤 (OS) 的发病率,人口统计,流行病学和生存率.
- 分析种族和种族对OS亚型和结果的影响.
- 通过使用国家注册数据,为中东的OS流行病学建立基线.
主要方法:
- 从2008年到2014年,对所有在伊朗国家癌症登记处 (INCR) 注册的OS患者进行了回顾性分析.
- 患者数据的统计评估,包括年龄,性别,癌症位置,OS亚型和生存时间.
- 计算年龄标准化发病率 (ASIR) 和生存分析.
主要成果:
- OS的ASIR为每百万人年3.02,平均年龄为25.6岁,男性和女性的比例为1.54:1.
- 其他未指定 (NOS) OS,冠状细胞OS和中央OS是最常见的亚型.
- 总体而言,一年,三年和五年生存率分别为87%,61%,49%.
结论:
- 伊朗的OS的ASIR与美国相当,高于中国,在15-19岁年龄组中发病率最高.
- 在伊朗患者中观察到的男性女性比率高于大多数报告的系列.
- 诊断时的年龄较大,轴性瘤位置和男性性别与预后较差有关,尽管在统计学上并不显著.
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