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在患有慢性病的患者中引起尿路感染的细菌的流行率和抗生素图
Tika Bahadur Thapa1,2, Sushant Pokhrel1, Anit Lamichhane1,2
1Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Soalteemode, Kathmandu, Nepal.
Open medicine (Warsaw, Poland)
|October 24, 2023
概括
尿路感染 (UTI) 影响15.8%的慢性病 (CKD) 患者,对常见抗生素具有高耐药性. 这凸显了对患有尿路感染的CKD患者进行细致抗生素选择的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 尿路感染 (UTI) 对慢性病 (CKD) 患者构成重大风险.
- 在CKD患者中有效管理尿路感染对于预防疾病进展和降低医疗保健成本至关重要.
- 了解CKD人群中尿路感染的流行率和抗生素耐药性模式对于最佳的治疗策略至关重要.
研究的目的:
- 为了确定慢性病 (CKD) 患者中尿路感染的患病率.
- 在这个患者群体中识别导致尿路感染的常见细菌病原体.
- 分析孤立细菌的抗生素敏感性模式.
主要方法:
- 从CKD患者中收集和微生物培养了482个中流尿样.
- 用于细菌隔离和鉴定的标准微生物技术.
- 使用Kirby-Bauer磁盘扩散方法进行抗生素敏感性测试.
主要成果:
- 在研究的482名CKD患者中观察到15.8%的尿路感染患病率.
- 主要的细菌分离物是大肠杆菌 (50%),空气真菌 (15.8%),菌 (15.8%),肺炎菌 (11.8%).
- 对β-乳酸抗生素 (例如,安西林94.7%) 发现了高耐药率,而聚素,胆素,万科米辛,美罗和伊米则表现出高灵敏度.
结论:
- 该研究显示,CKD患者中尿路感染和高抗生素耐药性有显著的患病率.
- 临床医生应考虑这些耐药性模式,在选择抗生素治疗尿路感染的CKD患者.
- 经验性抗生素治疗应由局部抗生素图指导,以确保治疗疗效.
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