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在自闭症谱系障碍中使用非侵入性脑刺激技术

Lindsay M Oberman¹, Sunday M Francis¹, Sarah H Lisanby¹

¹Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Autism research : official journal of the International Society for Autism Research

|October 24, 2023

概括

非侵入性脑刺激 (NIBS) 显示出治疗自闭症谱系障碍 (ASD) 症状的前景. 然而,关于安全性和有效性的数据有限,特别是在儿童中,这意味着广泛的非标签使用尚未得到支持.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
发育儿科发育儿科

背景情况:

像rTMS和tDCS这样的非侵入性脑刺激 (NIBS) 技术正在针对精神病和神经疾病进行探索.
目前,NIBS正在研究自闭症谱系障碍 (ASD) 的核心和相关症状.

研究的目的:

审查有关ASD症状的NIBS现有数据.
突出进一步研究的需要,包括更大的随机对照试验.

主要方法:

对ASD中NIBS应用的当前文献的综述.
对研究局限性的分析,包括样本大小和开放标签设计.

主要成果:

现有的关于ASD的NIBS研究往往是小规模的,开放的,并专注于有限的子组.
关于安全性和有效性的数据,特别是在儿童中,不足以支持广泛使用.

结论:

虽然NIBS有可能用于ASD治疗,但目前的证据不支持在该群体中广泛的非标签应用.
需要使用神经成像进行更大规模的随机对照试验,以确定ASD治疗反应的安全性,疗效和生物标志物.

关键词:

自闭症谱系障碍自闭症谱系障碍临床翻译临床翻译神经发育的神经发育非侵入性大脑刺激的非侵入性大脑刺激通过骨进行直流刺激.跨的磁性刺激

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