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在微型猪中自发性AA氨基粉症的病理特征

Misaki Inoue1, Shinya Miyazaki1, Natsumi Kobayashi1

  • 1Tokyo University of Agriculture and Technology, Tokyo, Japan.

Toxicologic pathology
|October 24, 2023
PubMed
概括

微型猪可以发展粉样蛋白A (AA) 粉样粉症,这种情况以前与家养猪的特定突变有关. 这项研究在微型猪中发现了AA氨基粉症与野生类型血清氨基粉素A (SAA),这表明环境因素可能影响疾病的呈现.

关键词:
粉样蛋白A 粉样蛋白化症粉样蛋白签名蛋白质的特征基因测序的基因测序免疫组织化学 免疫组织化学质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量微型皮人 微型皮蛋白质组分析 蛋白质组分析血清中的粉样蛋白A.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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