衰老对瘤微环境的影响以及对治疗的反应
Louise E Reynolds1, Seynab Maallin1, Scott Haston2
1Adhesion and Angiogenesis Lab, Centre for Tumour Microenvironment, Barts Cancer Institute, John Vane Science Centre, Queen Mary University London, UK.
The FEBS journal
|October 24, 2023
概括
细胞衰老可以阻止瘤生长,但也可以通过衰老相关的分泌表型 (SASP) 促进瘤生长. 针对老化,包括SASP,对于癌症治疗和理解瘤微环境相互作用至关重要.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 细胞衰老是一种稳定的细胞循环停止.
- 衰老涉及改变的基因表达和与衰老相关的分泌表型 (SASP).
- 衰老在癌症中具有双重作用:瘤抑制和促进.
研究的目的:
- 审查衰老如何影响瘤微环境.
- 讨论衰老在促进瘤发生,转移和治疗耐药性的作用.
- 概述目前针对癌症衰老的策略.
主要方法:
- 关于细胞衰老和癌症的文献综述.
- 分析与衰老相关的分泌表型 (SASP) 功能.
- 讨论老化剂,免疫清除和SASP向.
主要成果:
- 衰老可以细胞自主抑制瘤.
- 衰老可以通过SASP促进瘤,通过SASP对瘤微环境产生影响.
- SASP有助于细胞外矩阵重塑,免疫调节和血管变化.
结论:
- 衰老细胞及其SASP可以驱动侵略性的瘤表型.
- 针对衰老和SASP是一种有前途的治疗策略.
- 了解衰老对瘤微环境的影响,是有效治疗癌症的关键.
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