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静脉注射血栓抑制剂治疗在80岁以上的患者中的有效性和安全性
Vedat Ali Yürekli1, Burak Gürel2, Nihat Şengeze1
1Suleyman Demirel University, Isparta, Turkey.
The International journal of neuroscience
|October 24, 2023
概括
静脉栓塞治疗 (IVTT) 对80岁以上的患者是安全的,与未接受治疗的患者相比,其疗效和并发症率相似. 低剂量和标准剂量的复合组织等离子体激活剂 (rTPA) 也显示出可比的安全性和有效性.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 紧急医疗 紧急医疗
背景情况:
- 静脉输血凝聚剂疗法 (IVTT) 通常被批准用于80岁以下的患者.
- 关于IVTT在老年中风患者 (80岁以上) 的疗效和安全性的数据有限.
- 在这个人群中研究不同剂量的复合组织等离子体激活剂 (rTPA) 是至关重要的.
研究的目的:
- 评估80岁以上患者IVTT的功能结果和并发症率.
- 为了在这个年龄组中比较低剂量与标准剂量rTPA的疗效和安全性.
主要方法:
- 对80岁以上被诊断患有急性缺血性中风的患者进行了一项回顾性观察研究.
- 2016年8月至2021年4月期间,从两个医院收集了数据.
- 评估了第三个月修改的兰金度量 (mRS) 评分,死亡率和出血变化.
主要成果:
- 接受IVTT治疗的患者在第三个月显示出功能独立性增加的趋势 (mRS 0-2),尽管在统计学上不显著 (p=0.087).
- 在IVTT和非IVTT组之间,在死亡率或症状性脑内出血率方面没有发现统计学上显著的差异.
- 同样,在低剂量和标准剂量rTPA组之间没有观察到有效性或安全性的显著差异.
结论:
- 在80岁以上的患者中,IVTT似乎是安全和有效的,结果与未接受治疗的患者相似.
- 在低剂量和标准剂量rTPA之间做出选择不会显著影响该人群的疗效或安全性.
- 建议进行更大规模的研究,以进一步验证这些发现.
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