复星在类风湿病中的作用:系统性审查
Jozélio Freire de Carvalho1, Aaron Lerner2
1Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis (NUPEN), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.
European journal of rheumatology
|October 24, 2023
概括
Resveratrol显示出作为一种安全有效的抗氧化剂治疗类风湿性疾病的承诺,改善疼痛和炎症标志物. 需要进一步的广泛研究来证实这些初步发现.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 抗氧化剂研究的研究.
背景情况:
- 复星是一种天然的抗氧化剂,具有抗炎和细胞保护性质.
- 风湿性疾病包括一系列影响关节和结缔组织的炎症和自身免疫性疾病.
研究的目的:
- 审查目前关于复星在治疗各种类风湿性疾病中的疗效和安全性的文献.
- 综合现有研究中关于复星对疾病活动和炎症标志物的影响的发现.
主要方法:
- 在PubMed/Medline,Embase和Scielo数据库中进行了系统的文献搜索.
- 该审查包括了1966年1月至2023年3月期间发表的研究,重点关注复星和类风湿性疾病.
- 分析了五篇文章,涉及481名患有骨关节炎,类风湿性关节炎和高山动脉炎的患者.
主要成果:
- 服用白醇 (250-1000毫克/天) 表明疼痛强度,关节功能和疾病活性得分有所改善 (DAS 28).
- 观察到关键炎症标志物的显著减少,包括红细胞沉积率 (ESR),C反应蛋白 (CRP),IL-1,IL-6和TNF-alpha.
- 在包括的研究中没有报告任何不良副作用,这表明了有利的安全性.
结论:
- 复星似乎是几种类风湿病的安全治疗剂,对主观和客观疾病参数具有有前途的影响.
- 目前的证据是有限的,需要更大,更好的控制,双盲,交叉研究来验证这些发现并建立最终的治疗指南.
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