在患有自身免疫性炎症性风湿性疾病的患者中,流感疫苗类型依赖性抗体反应
Sofie Larsen Rasmussen1, Prabhat Kumar2, Ramona Trebbien3
1North Denmark Regional Hospital, Centre for Clinical Research, Hjoerring, Denmark.
European journal of rheumatology
|October 24, 2023
概括
与Vaxigrip和VaxigripTetra相比,使用Influvac接种流感疫苗在患有自身免疫性炎症性类风湿性疾病 (AIIRD) 的患者中产生了优异的抗体反应. 甲托雷克萨特治疗没有对这种免疫反应产生负面影响.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 研究自身免疫性炎症性类风湿性疾病 (AIIRDs) 患者的流感抗体反应.
- 基于2018-2019赛季在丹麦使用的不同流感疫苗类型的分层反应.
研究的目的:
- 为了比较不同流感疫苗在患有AIIRDs的患者中的免疫性.
- 评估生物修饰性抗风湿药物 (bDMARDs) 和甲状腺素对流感疫苗反应的影响.
主要方法:
- 包括患有类风湿性关节炎,牛皮性关节炎或脊椎关节炎的bDMARD患者.
- 记录了流感疫苗接种情况和疫苗类型;用血凝素抑制 (HAI) 试验测量了抗体标位.
- 计算了整体血清型HAI几何平均标位 (GMT),GMT≥40被认为是保护性的.
主要成果:
- 与Vaxigrip或VaxigripTetra相比,Influvac疫苗接种导致患者获得A/密歇根/H1N1和A/新加坡/H3N2的保护性HAI标位 (≥40) 的比例显著更高.
- 多变量分析证实了Influvac的优势,即使在调整了年龄,性别,甲状腺酸盐/普雷迪尼索隆治疗和疫苗接种史之后.
- 在205名患者中,约有51%接种了流感疫苗,约有四分之一达到保护性抗体水平.
结论:
- 与Vaxigrip和VaxigripTetra相比,Influvac在接受bDMARD治疗的AIIRD患者中显示出更强的流感抗体诱导.
- 在这个队列中,甲托雷克萨特治疗没有减弱对流感疫苗接种的抗体反应.
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