饮食组成,坚持卡路里限制,以及心脏代谢疾病风险修改
Sai Krupa Das1, Rachel E Silver1, Alistair Senior2,3,4
1Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Aging cell
|October 24, 2023
概括
饮食成分影响卡路里限制 (CR) 的遵守. 较高的蛋白质和碳水化合物摄入量,与较低的脂肪,与CALERIE试验中的更好的坚持相关,但不是心脏代谢标志物.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 心脏病学 心脏病学
背景情况:
- 卡路里限制 (CR) 显示出降低与年龄相关的疾病风险的潜力.
- 饮食组成对CR坚持和心脏代谢健康的影响仍然不清楚.
研究的目的:
- 调查宏观营养素组成和CR坚持之间的关联.
- 研究CR对心脏代谢风险因素的影响.
- 探索饮食指数和心脏代谢标志物之间的相关性.
主要方法:
- 利用营养的几何框架来分析宏观营养素摄入量.
- 使用随机对照试验设计 (CALERIE试验) 与CR和对照组.
- 通过斯皮尔曼相关性评估心脏代谢风险因素和饮食模式 (aMED,DII,HEI).
主要成果:
- 在24个月内,CR组增加了蛋白质和碳水化合物摄入量,同时减少了脂肪摄入量.
- 在碳水化合物丰富的饮食中摄入较高的蛋白质与更高的CR坚持相关.
- 在CR组中,没有发现宏观营养素组成和心脏代谢风险因素之间的直接相关性.
结论:
- 宏观营养素成分互动地影响CR坚持,而不是独立地.
- 饮食炎症指数 (DII) 和健康饮食指数 (HEI) 显示与心脏代谢因素有显著的相关性.
- 需要进一步的研究来了解宏观营养素的变化如何影响CR坚持和心脏代谢结果.
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