一个推动考虑成年人患白血病/淋巴瘤的地幔细胞淋巴瘤与形形态的压力
Nkechi Arinze1, Nivin Omar1, Amany Keruakous1
1Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Hematology reports
|October 24, 2023
概括
膜细胞淋巴瘤 (MCL) 是一种B细胞淋巴瘤. 这是一个没有典型的cyclin D1或CD5标记的独特案例,突出显示了SOX11和FISH在诊断布拉斯型MCL变体方面的重要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 膜细胞淋巴瘤 (MCL) 是一种中等级B细胞非霍奇金淋巴瘤,其特征是t(11;14) 转位导致环林D1过度表达.
- 典型的MCL免疫类型包括CD19,CD20,CD43,FMC7,BCL2,D1,CD5和SOX11.
研究的目的:
- 为了呈现一个独特的MCL病例,具有布拉斯形态.
- 讨论MCL中非典型免疫类型所带来的诊断挑战.
- 强调辅助研究在诊断具有挑战性的B细胞瘤中的重要性.
主要方法:
- 周围血液涂抹和骨髓活检检查.
- 对于CD20,CD10,CD5,环素D1和SOX11的免疫组织化学.
- 光现场杂交 (FISH) 用于t(11;14) 转移.
主要成果:
- 一名67岁的男性出现了严重的贫血症,血小板缩和白细胞病,具有布拉斯形态.
- 骨髓活检显示布拉斯托细胞对CD20和CD10呈阳性,但对CD5和环素D1.1呈阴性.
- SOX11呈阳性,而FISH证实了t(11;14) 转位,支持了布拉斯型MCL的诊断.
结论:
- 这种情况表明,MCL变异缺乏典型的环素D1和CD5表达,但对CD10和SOX11呈阳性.
- 在具有布拉斯形态的成年B细胞瘤中,应考虑MCL的布拉斯形态变异.
- 包括SOX11和FISH在内的全面辅助研究对于准确的诊断至关重要.
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