最近的趋势和风险因素与住院患者患有炎症性肠道疾病的Clostridioides difficile感染相关
Ellen J Spartz1,2, Lauren C DeDecker1,2, Kush M Fansiwala1,2
1Center for Inflammatory Bowel Diseases, UCLA School of Medicine, Los Angeles, California, USA.
Alimentary pharmacology & therapeutics
|October 24, 2023
概括
在患有炎症性肠病 (IBD) 的住院患者中,Clostridioides difficile感染 (CDI) 的发生率最初上升,但自2015年以来已经下降. 更高的并发病率和更大的医院与增加的CDI风险有关.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 医疗保健服务研究 医疗服务研究
背景情况:
- 克洛斯特里迪奥伊德困难感染 (CDI) 在炎症性肠病 (IBD) 患者中很普遍,通常模仿或恶化IBD爆发.
- 在IBD恶化期间,对CDI的及时诊断测试至关重要.
研究的目的:
- 分析住院IBD患者中CDI病例的最新趋势.
- 在这个人群中识别与CDI相关的风险因素.
- 为在IBD中预防CDI提供有针对性的干预信息.
主要方法:
- 全国再接收数据库 (2010-2020年) 的回顾性分析.
- 包括诊断为克罗恩病 (CD) 或性结肠炎 (UC) 的住院患者.
- 评估使用ICD代码和多变量逻辑回归进行风险因素分析的纵向CDI速率变化.
主要成果:
- 分析了超过250万IBD住院病例.
- 在IBD患者中的CDI率从2010-2015年增加,然后从2016-2020年下降.
- 增加的并发病率,公共保险和大型医院规模与更高的CDI率有关;CDI与死亡率的增加相关.
结论:
- 入院IBD患者的CDI率初步上升,随后在2015年后出现下降.
- 诸如并发症,医院规模,公共保险和城市教学地位等因素影响了CDI率.
- CDI与住院IBD患者的死亡率较高有关,强调需要继续感染控制和治疗.
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