迈向生物多样性基因组学最佳实践数据管理的旅程
Natalie J Forsdick1,2, Jana Wold2,3, Anton Angelo4
1Manaaki Whenua-Landcare Research, Lincoln, New Zealand.
Molecular ecology resources
|October 24, 2023
概括
生物多样性基因组学研究产生了庞大的数据集. 本研究确定了数据管理的挑战,并提供了最佳实践,包括一个新的在线中心,以改善数据的可访问性和研究人员的重复使用.
科学领域:
- 生物多样性基因组学 生物多样性基因组学
- 数据管理数据管理
- 生物信息学是一种生物信息学.
背景情况:
- 由于测序技术的进步和成本的降低,增加了大规模生物多样性基因组数据集的可访问性.
- 研究界对管理这些复杂数据集的最佳实践存在不确定性.
- 需要全面的数据管理指导,以尽量减少数据丢失,增强重复使用,并支持土著数据主权.
研究的目的:
- 确定生物多样性基因组学研究生态系统的数据管理挑战.
- 为有效的生物多样性基因组数据管理提供现实的考虑,妥协和行动.
- 支持研究人员在整个研究生命周期中嵌入数据管理,以最大限度地发挥影响.
主要方法:
- 开发了四个虚构人物,代表了与数据管理有关的各种用户体验.
- 利用这些人物来分析和突出数据管理的挑战.
- 启动生物多样性基因组学数据管理中心作为资源库.
主要成果:
- 确定生物多样性基因组学研究人员面临的具体数据管理挑战.
- 展示生物多样性基因组数据管理的实际方法和妥协方案.
- 建立生物多样性基因组学数据管理中心,提供实用资源和指导.
结论:
- 综合数据管理对于最大限度地提高生物多样性基因组数据的影响至关重要.
- 开发的人员和资源的目的是指导研究人员,特别是那些对数据管理新手,向最佳实践.
- 生物多样性基因组学数据管理中心是社区的宝贵工具,促进数据共享和重用.
相关概念视频
Evolutionary Relationships through Genome Comparisons
5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Genomics
36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.4K
Modern Molecular Taxonomy
26
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
26
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K


