唐氏综合征同时出现的条件:来自临床数据库的发现
Nicole T Baumer1,2,3, Margaret A Hojlo1, Katherine G Pawlowski1
1Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
概括
患有唐氏综合征 (DS) 的儿童经常出现视力,听力和胃肠道问题. 神经发育和心理健康状况是常见的,并且与DS中更多的医疗问题有关.
科学领域:
- 儿科医学 儿科医学
- 遗传学 是一个遗传学.
- 发育神经科学的发展神经科学.
背景情况:
- 患有唐氏综合征 (DS) 的个体通常具有同时出现的医疗和神经发育条件.
- 需要进行系统研究,以了解这些疾病对神经发育结果的患病率和影响.
研究的目的:
- 描述DS儿童中医疗,神经发育 (ND) 和心理健康 (MH) 疾病的患病率和关系.
- 评估医疗,ND和MH条件在这个人群中如何相互作用.
主要方法:
- 在一个专科医院创建了一个潜在的临床数据库,用于DS患者.
- 通过599名参与者的护理人员和临床医生报告收集了病情数据.
- 用频率和比较统计来分析条件关系.
主要成果:
- 观察到视力 (72.5%),耳朵/听力 (71.0%),胃肠道 (61.3%) 和呼吸道 (45.6%) 问题的高患病率.
- 神经发育 (ND) 和心理健康 (MH) 条件,包括自闭症谱系障碍和多动症多动症,影响了大约25%的儿童.
- 患有ND/MH疾病的儿童患病频率更高,特别是视力,耳朵/听力,胃肠道问题和先天性心脏病 (CHD).
结论:
- 系统地收集的数据显示,在患有DS的儿童中,同时出现的医疗,ND和MH疾病的患病率很高.
- 对DS患者的临床护理必须考虑医疗条件和神经发育之间的复杂相互作用.
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