来自马卡朗加无效的两个新的黄 pax & K.Hoffm
Mulyadi Tanjung1, Tjitjik Srie Tjahjandarie1, Muhammad Fajar Aldin1
1Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Natural product research
|October 24, 2023
概括
从马卡朗加无菌中分离出了两种新的异烯化黄醇,即MACAINERMISINS A-B. 这些化合物与已知的黄醇一起,对各种癌症细胞系表现出显著的抗癌活性.
科学领域:
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 马卡朗加 (Macaranga inermis) 是一种因其潜在的药用特性而闻名的植物物种.
- 黄类是植物二次代谢物的一类,具有多种生物活性,包括抗癌作用.
研究的目的:
- 从马卡朗加无菌中分离和表征新的异烯酸类黄.
- 评估与选择的癌症细胞系对隔离化合物的细胞毒性活性.
主要方法:
- 使用色谱技术分离化合物.
- 使用高分辨率电喷射电离质谱法 (HRESIMS),UV-Vis和核磁共振 (NMR) 谱法 (1D和2D) 阐明新化合物的结构.
- 使用WiDR,HeLa和4T1癌细胞系进行细胞毒性测定.
主要成果:
- 成功分离了两个新的异烯酸黄,马卡尼内米辛A-B (1-2),以及两个已知的化合物,黄P (3) 和布鲁索黄F (4).
- 化合物1对WiDR细胞具有较高的细胞毒性 (IC50 = 0.93μM).
- 化合物2和3对HeLa和WiDR (IC50 = 0.90-0.94μM) 和4T1和HeLa细胞 (IC50 = 0.83-0.98μM) 分别表现出显著的活性.
结论:
- 这项研究成功地从马卡朗加无效果中识别了新型异烯酸类黄.
- 隔离的化合物,特别是甲基尼尔米辛A-B和 sinoflavonoid P,对各种癌症细胞系具有强烈的细胞毒性作用,表明它们作为抗癌剂的潜力.
相关概念视频
Fruit Development, Structure, and Function
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Cellulose and Pectic Polysaccharides
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the parenchyma cells of...
As a cell matures, its cell wall specializes according to its type. For example, the parenchyma cells of...


