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西格玛1调节脂质滴滴介导的氧回归平衡,这是前列腺癌扩散所需的
Halley M Oyer1,2, Alexandra R Steck1,2, Charles G Longen1,2
1Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Cancer research communications
|October 24, 2023
概括
向Sigma1蛋白质会破坏前列腺癌中的脂质滴体恒温,通过防止活性氧物种封存来抑制扩散和瘤生长.
科学领域:
- 细胞生物学 细胞生物学
- 癌症新陈代谢 癌症新陈代谢
- 雷多克斯恒常状态 雷多克斯恒常
背景情况:
- 脂质滴 (LDs) 是参与细胞过程的关键代谢器官.
- 在前列腺癌中,LD积累与侵略性和不良结果相关.
- 雄激素受体 (AR) 信号驱动前列腺癌通过调节LDs,自和氧化应激.
研究的目的:
- 调查Sigma1/SIGMAR1在调节前列腺癌中脂质滴滴代谢中的作用.
- 阐明Sigma1抑制如何影响细胞氧化还原稳定和增殖.
主要方法:
- 研究了Sigma1在前列腺癌细胞系中的作用.
- 评估了Sigma1抑制对脂质,活性氧物种 (ROS) 水平和细胞增殖的影响.
- 与前列腺瘤中的脂质代谢和ROS途径相关的SIGMAR1转录水平.
主要成果:
- 西格玛1抑制触发了脂质,一种LD选择性自,防止LD积累.
- 这种干扰损害了活性氧物种 (ROS) 的封存,导致细胞增殖在体外被抑制.
- 在Sigma1向后,瘤生长在体内被显著抑制.
- 在前列腺瘤中,SIGMAR1转录水平与脂质代谢和ROS途径密切相关.
结论:
- 在前列腺癌中,Sigma1调节脂质滴体代谢和氧化还原平衡.
- 向Sigma1破坏了支持癌细胞增殖的代谢适应.
- 西格玛1代表了一种新的,在前列腺癌中具有药理目标的脆弱性.
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