相关实验视频

Updated: Jul 12, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

食道状细胞癌中的FOXP3表达:对 cetuximab 敏感性和治疗策略的影响

Shenghong Wu¹, Yu Wang², Zhijun Xiao³

¹Department of Medical Oncology, Fengxian District Central Hospital, 201499, Shanghai, China.

Wiener klinische Wochenschrift

|October 24, 2023

概括

在食道状细胞癌 (ESCC) 中准FOXP3 (分隔盒P3) 抑制细胞增殖和迁移. 沉默FOXP3增强对 cetuximab 治疗的敏感性,为ESCC提供潜在的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

食道状细胞癌 (ESCC) 是一个重要的全球健康问题.
转录因子分叉盒P3 (FOXP3) 在ESCC进展和治疗反应中的作用仍然不完全理解.

研究的目的:

研究FOXP3表达对ESCC细胞行为的影响.
确定FOXP3对ESCC细胞对 cetuximab向治疗的敏感性的影响.

主要方法:

使用合成的shRNA等离子体转移到TE12 ESCC细胞,实现了FOXP3基因沉默.
分别使用CCK-8和体外入侵试验来评估细胞增殖和入侵.
在体内疗效通过瘤发生试验在接受 cetuximab.com 治疗的裸体小鼠中进行评估.

主要成果:

沉默FOXP3基因显著降低了TE12细胞中的FOXP3mRNA和蛋白质表达.
沉默FOXP3导致细胞增殖的减少,侵袭的减少,并提高对 cetuximab 治疗的敏感性.
在体内研究表明,向FOXP3显著减少 cetuximab 治疗小鼠的瘤体积和肺转移.

结论:

高FOXP3表达促进ESCC细胞的增殖和迁移.
FOXP3 负面影响 ESCC 对 cetuximab 治疗的敏感性.
向FOXP3是一个有希望的治疗策略,可以改善ESCC患者的塞图西马布疗效.

关键词:

生物行为生物行为这种药物是Cetuximab.食道状细胞癌的癌症.这是FOXP3P3的.敏感度敏感度敏感度有针对性的治疗.

更多相关视频

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

相关概念视频

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...