针对循环中的瘤细胞,以防止转移
Karol Gostomczyk1,2, Mohammed Dheyaa Marsool Marsool3, Hamnah Tayyab4
1Department of Obstetrics, Gynaecology and Oncology, Chair of Pathomorphology and Clinical Placentology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland. karolgostomczyk.research@gmail.com.
Human cell
|October 24, 2023
概括
循环瘤细胞 (CTC) 是癌症扩散的关键指标. 准这些细胞并了解它们的相互作用提供了一种有希望的策略,可以预防转移并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 分子医学是分子医学.
背景情况:
- 循环瘤细胞 (CTC) 是从原发性瘤中分泌出来的,它们有助于转移.
- 在各种癌症类型中,CTC存在与癌症进展和更差的预后相关.
- 由于瘤异质性,了解CTC对于个性化癌症治疗至关重要.
研究的目的:
- 探索CTCs在癌症转移中的作用.
- 调查表皮-介质细胞过渡 (EMT) 和介质细胞-表皮细胞过渡 (MET) 在CTC生成中的意义.
- 讨论潜在的治疗点和CTC的检测标记.
主要方法:
- 在血液和体液中分析CTC.
- 研究涉及EMT/MET的蛋白质标记物 (EpCAM,维丁,CD44,TGM2).
- 对CTC的检测设备,方法和协议的审查.
- 检查CTC与瘤微环境的相互作用,包括与瘤相关的巨细胞.
主要成果:
- CTC与癌症的进展和转移有关.
- EMT和MET是CTC传播的关键过程.
- 像EpCAM,vimentin,CD44和TGM2这样的蛋白质与CTC调节有关,是潜在的治疗点.
- 与瘤微环境组件的CTC相互作用,如巨细胞,促进免疫逃避和转移.
结论:
- 准CTC及其相关途径对预防转移有很大的希望.
- 制定减少CTC体积和消除它们的策略可以改善患者的治疗结果.
- 对针对CTC的向疗法的进一步研究对于推进癌症治疗至关重要.
相关概念视频
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K


