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相关实验视频

Updated: Jul 12, 2025

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

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一个支持光学纳米纤维的芯片单纳米粒子传感器.

Ning Liu1, Ni Yao2, Shipeng Wang2

  • 1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhang_lei@zju.edu.cn.

Lab on a chip
|October 24, 2023
PubMed
概括
此摘要是机器生成的。

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本研究介绍了一种光学纳米纤维微流体传感器,用于检测和尺寸纳米粒子. 该传感器实现了单个纳米粒子检测和尺寸分析,显示了病毒检测应用的潜力.

科学领域:

  • 光学和光子学 在光学和光子学.
  • 纳米技术 纳米技术
  • 微流体学 微流体学

背景情况:

  • 单个纳米粒子检测对于基础物理和生物应用至关重要.
  • 现有的方法往往在灵敏度和吞吐量方面面临限制.
  • 微流体设备在微尺度上对样品处理提供精确的控制.

研究的目的:

  • 开发和演示用于纳米粒子检测和尺寸的光学纳米纤维支持的微流体传感器.
  • 为了实现解决方案中纳米颗粒的无标签,高通量分析.
  • 探索传感器在生物应用中的潜力,包括病毒检测.

主要方法:

  • 利用光学纳米纤维的 evanescent 领域进行纳米粒子散射检测.
  • 采用微流体通道将纳米颗粒限制在 femtoliter 的检测体积中.
  • 通过纳米粒子相互作用引起的传输光强度变化的实时监测.
  • 对用于纳米粒子尺寸确定的散射信号进行统计分析.

主要成果:

  • 成功检测和尺寸的单个聚乙烯纳米粒子到100纳米.
  • 区分不同尺寸 (200,500,1000纳米) 的纳米颗粒混合物.
  • 证明了酵母细胞的高通量计数和光纳米粒子的双波长检测.

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  • 在溶液中成功检测出异构体.

    • 结论:

    • 光学纳米纤维微流体传感器使得纳米颗粒的敏感,无标签的检测和尺寸.
    • 该系统展示了高吞吐量和多重传感的潜力.
    • 这项技术有望快速检测各种病毒和其他生物分析物.