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设计各种基于纳米载体的混合催化剂的策略,用于增强化学动力学癌症治疗

Ji-Na Hao¹, Kaiming Ge¹, Guoli Chen¹

¹Lab of Low Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. ysli@ecust.edu.cn.

Chemical Society reviews

|October 24, 2023

概括

化学动力学疗法 (CDT) 通过在瘤微环境中产生有毒的基激素来增强癌症治疗. 本综述侧重于治疗活性纳米载体,以提高CDT效率和临床转化.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

化学动力学疗法 (CDT) 使用芬顿/芬顿类反应来产生基激素 (̇OH) 在瘤微环境 (TME) 内致癌细胞死亡.
CDT的效率受到TME因素的限制,如轻度酸度,低H2O2水平和高度的谷,阻碍了临床应用.
协同作用的策略和基于纳米载体的系统对于克服这些局限性和提高CDT有效性至关重要.

研究的目的:

综合审查以纳米载体为基础的系统,用于增强化学动力学治疗的最新进展.
专注于具有固有的治疗能力,减少毒性和代谢负担的治疗活性纳米载体.
引导多功能纳米系统的设计,以改善CDT和潜在的临床转化.

主要方法:

关于基于纳米载体的化学动力学治疗系统的最新研究的文献综述.
对将芬顿剂整合到纳米载体中的策略进行分析.
重点是开发和应用用于CDT的治疗活性纳米载体.

主要成果:

纳米载体是向瘤提供芬顿催化剂和治疗剂的关键,增强CDT的特异性.
治疗活性纳米载体通过结合药物输送和治疗功能提供了一个有希望的方法.
将芬顿剂集成到纳米载体中可以显著提高CDT的效率.

结论:

基于纳米载体的系统,特别是治疗活性系统,对于推进化学动力学治疗至关重要.
优化纳米载体设计和芬顿剂集成对于最大限度地提高CDT疗效至关重要.
需要进一步的研究和开发,以临床翻译这些先进的癌症治疗疗法.

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