在COVID-19后的运动呼吸反应:在门诊和住院患者之间的比较
Ivan Guerreiro1,2, Aurélien Bringard1, Mayssam Nehme3
1Division of Pneumology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
概括
患有COVID-19后呼吸障碍的患者在运动期间显示呼吸效率低下. 与住院患者相比,门诊患者的呼吸反应效率较低,突出显示需要详细的心肺运动测试分析.
科学领域:
- 肺部医学 肺部医学
- 心血管呼吸系统生理学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19呼吸障碍往往与运动期间呼吸系统反应效率低下有关.
- 在SARS-CoV-2感染后,在住院和门诊患者中观察到这种效率低下.
- 这些群体之间的呼吸反应差异的根本原因尚不清楚.
研究的目的:
- 为了比较在门诊 (AMBU) 和住院 (HOSP) 患者之间的运动呼吸器反应,这些患者在COVID-19后有持续的呼吸症状.
- 调查COVID-19的严重程度是否影响运动能力和呼吸系统效率.
- 为了确定详细的心肺运动测试 (CPET) 分析是否可以更好地识别呼吸系统低效率.
主要方法:
- 分析了来自79名患者 (42名AMBU,37名HOSP) 的CPET数据,这些患者在COVID-19后3个月出现了持续症状.
- 收集的数据包括胸部CT扫描,肺功能测试和生活质量问卷.
- CPET数据被专门分析为通风 (V·e) 和时间的函数,而不仅仅是峰值值.
主要成果:
- 在AMBU和HOSP组之间,峰值氧气吸收 (V·o2) 没有显著差异.
- 与住院患者相比,在运动结束时,门诊患者的潮体积 (VT) 与通风 (V̇e) 相比较低 (P < 0.01).
- 两组都显示出V·e-CO2生产斜率升高,表明呼吸器反应异常.
结论:
- COVID-19的严重程度没有影响整体运动能力.
- 门诊患者表现出对运动的呼吸反应效率低于住院患者,尽管运动能力相似.
- 在整个运动过程中分析呼吸系统数据,而不仅仅是峰值值,对于检测COVID-19后的呼吸系统低效率至关重要.
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