在多民族动脉样硬化研究 (MESA) 中,血清对素蛋白/抗原和左心室结构和功能的反应性
Jan M Hughes-Austin1, Ronit Katz2, Darcy S Majka3
1Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, California, United States of America.
PloS one
|October 24, 2023
概括
对素蛋白抗体的高反应性与没有心力衰竭的个体的左心室喷射率 (LVEF) 降低有关. 这种关联表明亚临床心肌变化,但不能预测发生的心力衰竭.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 与左心室 (LV) 结构和功能的改变有关.
- 抗体对素蛋白抗原的抗体可以在RA发病前几年被检测出来.
- 这些抗体与一般人群中亚临床心脏变化之间的联系尚不清楚.
研究的目的:
- 调查血清对素蛋白/抗原的反应性与LV结构和功能之间的关联.
- 为了确定这种反应性是否预测发生心力衰竭 (HF) 在没有基线HF的个人中.
主要方法:
- 在1232名多民族动脉样硬化研究 (MESA) 参与者中测量了28种素蛋白/抗原的血清反应性.
- 定义了极高反应性 (EHR) 抗体 (>95百分位数).
- 使用回归模型分析了与 LV 质量,LV 射出分数 (LVEF) 和事件 HF 的关联,并对多个共变量进行了调整.
主要成果:
- 27%的参与者对至少一种抗原有EHR抗体.
- 每个额外的EHR抗体都与LVEF (完全调整后) 减少0.1%有关.
- 在EHR抗体和LV质量或事件HF之间没有发现显著的关联.
结论:
- 对素蛋白/抗原的反应性增加与较低的LVEF相关,表明微妙的亚临床心肌收缩性变化.
- 这些关于发生心力衰竭的发现的临床意义仍然不确定.
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