患有Blastoid和pleomorphic变异的地幔细胞淋巴瘤患者的结局
James N Gerson1,2, Elizabeth Handorf1, Diego Villa3
1Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Blood advances
|October 24, 2023
概括
斑块状和多形地幔细胞淋巴瘤 (MCL) 变种的预后不好. 自主造血干细胞移植改善了无进展的存活率,但并没有改善这些侵袭性MCL亚型的整体存活率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 膜细胞淋巴瘤 (MCL) 是一种具有攻击性的B细胞非霍奇金淋巴瘤.
- 与其他MCL亚型相比,布拉斯托型和多形MCL变异与更差的预后有关.
研究的目的:
- 描述患有布拉斯型/形MCL变异的患者的临床特征和结果.
- 确定影响无进展生存 (PFS) 和总生存 (OS) 的预后因素.
主要方法:
- 对2000年至2015年间被诊断患有MCL的成年患者的回顾性分析.
- 评估了1029个MCL病例,重点关注207个被确定为布拉斯或形变体.
- 统计分析以确定与PFS和OS相关的因素,包括自身造血干细胞移植 (auto-HCT) 和MCL国际预后指数 (MIPI) 评分.
主要成果:
- 在布拉斯托形/形MCL队列中,PFS的中位数为38个月,OS的中位数为68个月.
- 接受自动HCT与改善PFS (HR,0.52) 相关,但没有OS (HR,0.69).
- 较高的MIPI得分和自动HCT的资格不合格与更糟糕的生存结果有关.
结论:
- 自主造血干细胞移植可能会改善有资格的患有布拉斯托类/多形性MCL变异的患者的无进展生存率.
- 国际MCL预后指数仍然是预测这些侵袭性MCL亚型的结果的关键工具.
- 进一步的研究是有必要的,以优化治疗策略,为患者的布拉斯型/形MCL变体.
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