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老动脉中受损的平衡,通过对弹性叶片的微观结构研究揭示了
Anastasia Gkousioudi1, Taisiya Sigaeva2, Xunjie Yu1
1Department of Mechanical Engineering, Boston University, Boston, MA, United States.
Journal of the mechanical behavior of biomedical materials
|October 24, 2023
概括
衰老通过改变弹性叶片变形,危及动脉平衡. 衰老的动脉表现出不均的叶片间空间,导致非均的叶片拉伸和增加压力在 adventitia.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 机械生物学 机械生物学
背景情况:
- 动脉壁通过适应刺激来维持机械平衡.
- 老龄化会破坏这种恒常的微环境.
- 弹性叶片中的结构异质性使应力分布均.
研究的目的:
- 为了研究衰老对弹性叶片变形的影响.
- 了解衰老如何影响动脉机械恒温.
- 为了识别老化动脉中的微观结构变化.
主要方法:
- 来自老年小鼠的常见动脉使用多光子显微镜进行成像.
- 动脉在不同压力下 (0-120 mmHg) 被双轴延伸和膨胀.
- 从重建的图像中量化了状片的展开和拉伸.
主要成果:
- 与年轻的动脉相比,老化的弹性叶片在内层显示出更大的展开.
- 在老年动脉中观察到皮层间空间的不均增加.
- 这导致了非均的叶片拉伸,升高的应力梯度,以及负载转移到 adventitia.
结论:
- 衰老破坏了维护动脉机械平衡的微观结构机制.
- 老化动脉中变化的叶片变形有助于不利的机械行为.
- 研究结果强调了微观结构变化在与年龄相关的动脉功能障碍中的作用.
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