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使用紫外线光谱检测COVID-19的呼气分析的可行性研究

Saurin R Sutaria¹, James D Morris², Zhenzhen Xie²

¹Departments of Chemistry, University of Louisville, Louisville, KY 40292, United States of America.

Journal of breath research

|October 24, 2023

概括

这项研究表明,呼吸样本上的紫外线吸收可以检测到COVID-19. 该方法使用微反应器在呼出的呼吸中分析碳类挥发性有机化合物.

科学领域:

生物化学生化学
分析化学分析化学
医学诊断医学诊断医学诊断

背景情况:

包括COVID-19在内的病毒感染可能会改变新陈代谢过程,导致呼出的挥发性有机化合物 (VOC) 发生变化.
在呼吸中检测特定的VOC提供了一种非侵入性的疾病诊断方法.

研究的目的:

评估使用呼气样本的紫外线吸收度测量以检测COVID-19的可行性.
研究微反应器技术在预先缩和分析呼出的碳类挥发性有机物方面的潜力.

主要方法:

从23名受试者 (COVID-19阳性和健康对照) 收集了呼气样本.
使用的微反应器用于碳类挥发性有机化合物的化学选择性预度.
对收集的样本进行了甲醇化和随后的紫外线吸收性分析.
在235nm至305nm波长范围内分析了吸收光谱.

主要成果:

在健康和有症状的COVID-19阳性受试者之间观察到紫外线吸收值的统计学上显著差异.
观察到的差异主要在235nm至305nm波长范围内.
这项研究支持了这种假设,即病毒感染增加了呼出的碳酸.

结论:

通过微反应器分析的呼吸样本上的紫外线吸收度测量显示,对非侵入性COVID-19检测有希望.
需要进一步的研究来验证这些发现,并探索潜在的混因素,如年龄.

关键词:

在 COVID-19 疫情中,紫外线光谱法紫外线光谱法这是一种VOC,可挥发性化合物.诊断诊断诊断诊断诊断诊断呼出的气息呼出的气息在度前进行预度.

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