超热:用于空间有限的磁粒子超热的临床前装置
Hayden Carlton1, Matthias Weber2, Maximilian Peters2
1Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
概括
磁粒子高温使用磁纳米粒子和交替磁场来治疗癌症. 一种名为HYPER的新设备精确地控制了选定的区域的加热,克服了纳米粒子高热治疗癌症的能量传递挑战.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 磁粒子高温症 (MPH) 是一种成熟的癌症治疗方法,利用磁纳米粒子 (MNP) 和交替磁场 (AMF) 来产生局部的热量.
- 来自MPH的热应激可以直接杀死癌细胞或使其对辐射等常规治疗敏感.
- 在MPH的一个关键挑战是实现精确控制能量沉积,以有效地准瘤组织.
研究的目的:
- 设计和实施一个原型临床前设备,HYPER,用于空间限制的纳米粒子加热.
- 为了使用户选择控制在一个定义的区域内MNP供暖的数量和位置.
- 为了解决在磁粒子高温中改善空间能量传递控制的关键需求.
主要方法:
- 该HYPER设备使用一个AMF线圈 (340kHz,0-15mT) 放置在两个对立的永久磁铁之间,以创建可调的磁场梯度.
- 梯度决定了无场区域 (FFR) (0.8-35厘米) 的大小,MNP通过hysteresis损失产生热量.
- 图形用户界面 (GUI) 允许用户选择FFR的位置 (3D空间) 和梯度,线性执行器相应地调整磁铁的位置.
主要成果:
- 该设备成功地在用户定义的体积和位置内实现了空间限制的纳米粒子加热.
- 验证了幻体内两个不同的纳米颗粒丰富区域的独立加热,证明了精确的空间控制.
- 该系统允许精确操纵FFR,控制有效MNP加热的区域.
结论:
- 在临床前应用中,HYPER原型证明了对纳米粒子加热的有效空间控制.
- 这项技术有可能显著提高磁粒子高温治疗癌症的精度和疗效.
- 精确控制能量传递对于优化热疗法和最大限度地减少非目标效应至关重要.
更多相关视频
06:45In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
4.3K
13:41Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Published on: January 13, 2023
2.4K
相关概念视频
01:29Decreased Body Temperature
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
01:13Equipments Used to Measure Body Temperature
Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...