双甲状腺视神经病变的视觉功能变化和ROC曲线分析用于早期诊断指标
Sha Wang1,2,3, Jinwei Wang4,5,6, Lu Chen4,5,6
1Eye Center, Xiangya Hospital, Central South University, Changsha 410008. wangsha_1982@csu.edu.cn.
概括
甲状腺视神经病变 (DON) 损害视力. 这项研究发现视野指数和对比度灵敏度是早期DON诊断的关键指标,有助于及时干预.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺视觉神经病变 (DON) 在患有甲状腺相关眼科医症的患者中对视力构成重大威胁.
- 早期和准确的DON诊断对于有效的管理和视力保护至关重要.
研究的目的:
- 研究诊断为DON的患者视觉功能的变化.
- 评估各种DON的临床指标的诊断价值.
主要方法:
- 一项对49名DON患者98只眼睛的回顾性分析.
- 评估的最佳校正视敏度 (BCVA),汉弗雷视野 (HVF),视觉唤起潜力 (VEP) 和对比度敏感度 (CS).
- 使用ROC曲线分析来确定诊断指标的灵敏度和特异性.
主要成果:
- DON患者表现出显著降低的BCVA和视野指数 (VFI),以及平均偏差 (MD) 和模式标准偏差 (PSD) 的升高.
- 在DON眼中,对比度敏感性,特别是在中频率 (CSM) 中,显著下降.
- VEP显示P100波幅降低,在特定空间频率的延长延迟,CSM显示最高的诊断准确性.
结论:
- 在DON患者中,视觉功能明显受损.
- VFI,对比度灵敏度 (低,中,高频) 和15°P100波幅显示出作为DON的有效早期诊断标记物的潜力.
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