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外源H2S启动Nrf2/GPx4/GSH通路,通过促进糖尿病心脏中的Syvn1-Keap1相互作用

Mengyi Wang1, Jingyuan Tang1, Shiwu Zhang1

  • 1Department of Pathophysiology, Harbin Medical University, 150081, Harbin, China.

Cell death discovery
|October 24, 2023
PubMed
概括

硫化 (H2S) 通过激活Nrf2/GPx4/GSH通路来保护糖尿病心肌病. 这种机制涉及Syvn1介导的Keap1无处不在,减少心脏细胞中的铁和线粒体亡.

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