鱼类中的硫胺酶的进化和生态相关物
Freya E Rowland1, Catherine A Richter2, Donald E Tillitt2
1U.S. Geological Survey, Columbia Environmental Research Center, 4200 New Haven Rd, Columbia, MO, 65201, USA. frowland@usgs.gov.
Scientific reports
|October 24, 2023
概括
鱼类中的胺酶与胺缺乏有关,它不是进化性的,而是由生态因素驱动的. 鱼类在食物网的较低位置食,高含omega-3脂肪酸,在淡水和热带气候中食,更有可能产生硫胺酶.
科学领域:
- 生物化学 生物化学
- 生态生态学 生态生态学
- 进化生物学 进化生物学
背景情况:
- 胺 (维生素B1) 对所有生物体都至关重要,但缺乏它会导致严重的健康问题.
- 胺酶是一种在某些鱼类中发现的酶,会降解胺,导致缺乏.
- 对鱼类和人类健康至关重要的是了解鱼类中的硫胺酶生产.
研究的目的:
- 调查鱼类中硫胺酶生产的驱动因素.
- 为了确定进化史,鱼类特征或环境条件是否预测了硫胺酶活性.
- 为了确定与胺酶存在相关的生态因素.
主要方法:
- 文献综述和GenBank BLAST在300种鱼类中搜索硫胺酶活性和序列同质性.
- 统计分析以将硫胺酶存在与进化关系,热量水平,脂肪酸含量,息地,气候,入侵潜力和身体大小相关联.
主要成果:
- 提亚胺酶活性与鱼类基因的进化史没有相关性.
- 生态因素显著预测了硫胺酶的存在.
- 鱼类在食物网的较低位置食,高含多不和脂肪酸,居住在淡水和热带气候地区的鱼类更有可能表达硫氨酶.
结论:
- 鱼类中的硫胺酶产生主要是由生态和环境因素驱动的,而不是进化血统.
- 这些发现有助于识别可能构成胺缺乏风险的鱼类.
- 了解胺酶来源对于管理渔业和预防生鱼消费者的健康问题至关重要.
相关概念视频
Riboswitches
8.1K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.1K
Trophic Efficiency
20.6K
Trophic level transfer efficiency (TLTE) is a measure of the total energy transfer from one trophic level to the next. Due to extensive energy loss as metabolic heat, an average of only 10% of the original energy obtained is passed on to the next level. This pattern of energy loss severely limits the possible number of trophic levels in a food chain.
20.6K
Enzyme Inhibition
78.5K
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
78.5K
Osmoregulation in Fishes
49.7K
When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
49.7K
Speciation Rates
21.2K
Overview
21.2K
Enzyme Kinetics
97.0K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
97.0K


