感染性内心炎的性别差异:丹麦全国性的研究
Anna Stahl1, Lauge Østergaard2, Eva Havers-Borgersen2
1The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. annastahl118@gmail.com.
Infection
|October 24, 2023
概括
与男性相比,患有传染性内心炎 (IE) 的女性患者在医院内死亡率较高,但长期存活率相似. 这项研究强调了IE特征和管理中的基于性别的差异.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在传染性内心炎 (IE) 中注意到性别差异,但患者的特征和结果仍然很少被记录.
- 关于与性别相关的短期IE结果的相互矛盾的数据需要进一步的大规模调查.
研究的目的:
- 在IE中全面描述性别差异.
- 在国家一级分析患者人口统计,脆弱性,微生物学,社会经济地位,治疗和结果的差异.
主要方法:
- 利用丹麦国家注册 (2010-2020年) 通过ICD代码和实验室报告来识别IE患者.
- 使用医院脆弱风险评分评估脆弱性.
- 在调整后的死亡率分析中使用后勤和考克斯回归.
主要成果:
- 包括6259名IE患者 (32.7%为女性). 女性患者年龄较大,身体较脆弱,并较少出现肠球菌-IE病例.
- 女性患者接受手术的频率较少 (14.0%对21.2%).
- 女性性别与增加的住院死亡率相关 (adj. OR 1.33),但不包括退院后1年或5年死亡率.
结论:
- 女性性别与IE患者的住院死亡率较高有关.
- 观察到的差异包括较低的Enterococcus-IE流行率和女性手术干预率的降低.
- 需要进一步的研究来阐明这些观察到的基于性别的差异的根本原因.
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