Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Molecular Dynamics Simulations of Polyelectrolyte Complexes.

Biomacromolecules·2024

Same author

Deciphering the Role of π-Interactions in Polyelectrolyte Complexes Using Rationally Designed Peptides.

Polymers·2021

Same author

Structural transitions and encapsulation selectivity of thermoresponsive polyelectrolyte complex micelles.

Journal of materials chemistry. B·2019

Same author

Engineering Peptide-Based Polyelectrolyte Complexes with Increased Hydrophobicity.

Molecules (Basel, Switzerland)·2019

Same journal

Reaction Optimization for Enzymatic Deconstruction of Industrially Relevant Nylon Composites.

Chembiochem : a European journal of chemical biology·2026

Same journal

Deploying Artificial Metalloenzymes in Complex Environments: Strategies and Applications.

Chembiochem : a European journal of chemical biology·2026

Same journal

Synthetic Ligands of Myeloid C-Type Lectin Receptors.

Chembiochem : a European journal of chemical biology·2026

Same journal

Vancomycin-Mediated Binding of DNA Origami Nanostructures to Gram-Positive and Gram-Negative Bacteria.

Chembiochem : a European journal of chemical biology·2026

Same journal

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues.

Chembiochem : a European journal of chemical biology·2026

Same journal

Pressure-Dependent Aromatic Ring Flips Reveal Variable Transition-State Volume and Compressibility Among Structural Regions of BPTI.

Chembiochem : a European journal of chemical biology·2026

查看所有相关文章

Search research articles

相关实验视频

Updated: Jul 12, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

通过基于的多电解质复合物进行药物封装.

Sara Tabandeh¹, Tahoora Ateeq¹, Lorraine Leon^1,2

¹Department of Materials Science and Engineering, University of Central Florida, 12760 Pegasus Dr, Orlando, FL-32816, USA.

Chembiochem : a European journal of chemical biology

|October 24, 2023

概括

此摘要是机器生成的。

酸聚电解质复合物有效地封装了诸如多克索鲁比辛和甲基蓝等药物. 在序列中,更高的电荷密度和疏水性提高了药物载荷和药物输送应用的复杂稳定性.

关键词:

协同坚持的一致性.封装的封装方式聚电解质复合物的复合物.这是一种多类聚.自动组装的自动组装机

更多相关视频

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Published on: April 12, 2024

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

相关实验视频

Last Updated: Jul 12, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Published on: April 12, 2024

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
药物输送系统药物输送系统

背景情况:

基于的多电解质复合物提供可调节的特性,用于封装各种分子.
了解分子相互作用是设计有效药物递送载体的关键.

研究的目的:

在合理设计的多序列中研究模型药物的封装效率和稳定性.
阐明电荷密度和疏水性在类药物相互作用和复合物形成中的作用.

主要方法:

紫外线-紫外线光谱学
光显微镜的光学显微镜.
红外光谱学红外光谱学红外光谱学

主要成果:

由于离子相互作用,封效率随着更高的质电荷密度而增加.
疏水性显著增强了 doxorubicin (DOX) 和甲基蓝 (MB) 在类似电荷密度的封装.
甲蓝封装改变了复杂的稳定性,导致高电荷和疏水性序列的液态到固态相变.

结论:

离子和疏水相互作用对于有效封装难溶药物至关重要.
聚酸序列设计,平衡电荷密度和疏水性,可以控制药物负载和输送复合物的物理性质.
这些发现为开发先进的基于的药物递送载体提供了洞察力.