在中风相关的肺炎患者中,口腔微生物失生症和功能不良结果之间的关联
Yueran Ren1, Jingru Liang1, Xiao Li1
1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
BMC microbiology
|October 24, 2023
概括
口腔的微生物组
科学领域:
- 微生物组研究的研究.
- 神经学 神经学
- 传染性疾病传染性疾病.
背景情况:
- 口腔微生物组在中风相关肺炎 (SAP) 中的作用尚未得到充分研究.
- 了解口腔微生物的变化对于治疗中风并发症至关重要.
研究的目的:
- 在SAP患者中分析口腔微生物组成.
- 调查微生物组的时间不稳定性和与肺炎进展和功能结果相关的特定种群.
主要方法:
- 对急性缺血性中风 (AIS) 患者的前性,观察性,单中心队列研究.
- 在多个时间点通过16SrRNA测序分析的口腔拭子.
- 在非肺炎,SAP和呼吸机相关肺炎 (VAP) 组中,口腔微生物群的比较.
主要成果:
- SAP和VAP患者在住院期间显示出显著的动态口腔微生物群差异和增加的不稳定性.
- 链球菌的较低丰度与较高的SAP风险有关.
- 增加的Actinobacteriota种类与糟糕的结果相关.
- 口腔微生物群模型准确地预测了SAP患者的30天结果.
结论:
- 特定的口腔微生物群签名可以预测SAP的发展和临床结果.
- 口腔微生物群显示出作为SAP管理的非侵入性诊断生物标志物的潜力.
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