suPARnostic:用于检测细胞癌复发的先进预测工具
Nessn Azawi1,2, Karina Sif Sondergaard Mosholt3, Nathalie Demuth Fryd4
1Department of Urology, Zealand University Hospital, Sygehusvej 6, Roskilde, 4000, Denmark. nesa@regionsjaelland.dk.
BMC urology
|October 24, 2023
概括
高血suPAR水平表明癌患者的复发风险增加和存活时间减少. 可溶性尿基酶类型等离子素激活受体 (suPAR) 显示为监测细胞癌 (ccRCC) 的生物标志物具有前途.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 细胞癌研究 细胞癌研究
背景情况:
- 血溶性尿基酶类型的血原激活受体 (suPAR) 已被认为可以预测细胞癌 (ccRCC) 的疾病攻击性.
- 在ccRCC中suPAR的预后准确性以前没有被研究过.
研究的目的:
- 为了研究手术前血suPAR的预后准确性.
- 评估suPAR在最初局部化ccRCC的患者中进行治愈治疗的预测价值.
主要方法:
- 从235名ccRCC患者 (2010-2015年) 的血样本进行了回顾性分析.
- 使用单变量和多重逻辑Cox回归分析来将suPAR水平与患者的结果相关联.
主要成果:
- 升高的suPAR (≥6 ng/mL) 与较差的整体存活率 (OS) 和无复发存活率 (RFS) 显著相关.
- 高suPAR患者的复发风险增加了2.3倍 (HR).
- 在多变量分析中,suPAR仍然是OS和RFS的独立负预测指标.
结论:
- 在ccRCC患者中血SUPAR度升高与更高的复发风险和减少的生存寿命相关.
- suPAR成为一种潜在的液体生物标志物,可以改善患者监测和早期检测ccRCC中复发的情况.
- suPAR独立预测癌各个阶段患者的生存结果.
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